Professor of Cognitive Neuroscience Β· MIT

Understanding
the Human
Mind

Pioneering research at the intersection of artificial intelligence,
neural computation, and cognitive psychology.

24+ Years Research
180+ Publications
12K+ Citations
$4.2M Grants Secured
Photo
🧠 Neural Networks
πŸ€– AI Research
πŸ“Š Data Science
Biography

About Me

Dr. Eleanor Shaw is a Full Professor and the inaugural holder of the Weissman Chair in Cognitive Sciences at the Massachusetts Institute of Technology.

With over two decades of interdisciplinary research, her lab explores how the brain encodes, retrieves, and restructures memory β€” and how those mechanisms can inform next-generation AI. Her work bridges neuroscience, computational modeling, and clinical translation.

Dr. Shaw earned her PhD from Stanford University and completed postdoctoral fellowships at the Salk Institute and the Max Planck Institute for Brain Research. She currently leads the Cognitive Computation Lab (CCL) and serves as Associate Director of MIT's Brain & Cognitive Sciences Department.

Neuroscience Machine Learning Memory Systems Computational Modeling fMRI Research Neuroplasticity
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Education

Ph.D. Neuroscience, Stanford University, 2001

B.Sc. Biophysics, Yale University, 1996

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Affiliations

MIT Brain & Cognitive Sciences Dept.

McGovern Institute for Brain Research

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Lab

Cognitive Computation Lab (CCL)

Building 46, Room 4082, MIT

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Languages

English (Native), French (Fluent)

German (Professional)

Areas of Focus

Research Interests

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Memory & Neural Encoding

Investigating how episodic and semantic memories are consolidated during sleep and how hippocampal-neocortical circuits drive long-term potentiation.

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Neuro-Inspired AI

Designing artificial neural networks whose architecture mirrors biological memory systems, enabling more robust generalization and catastrophic forgetting resistance.

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Clinical Translation

Translating lab findings into therapeutic interventions for Alzheimer's, PTSD, and age-related memory decline via targeted neuromodulation.

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Computational Psychiatry

Building Bayesian models of decision-making under uncertainty to understand maladaptive learning patterns underlying anxiety and addiction.

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Connectome Mapping

Large-scale structural and functional connectivity analysis using graph-theoretic methods to map individual-difference signatures across the lifespan.

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Epigenetics of Learning

Exploring how environmental stressors and enrichment experiences alter gene expression patterns that shape synaptic plasticity and memory capacity.

Selected Works

Recent Publications

2024
Journal

Hippocampal sharp-wave ripples mediate offline memory reactivation in the human cortex

Shaw, E., Nakamura, T., Patel, R., & Diekelmann, S.

Nature Neuroscience, 27(4), 612–628

PDF DOI Cite πŸ”– 142 citations
2024
Journal

Catastrophic forgetting mitigation via hippocampal complementary learning systems in transformer architectures

Shaw, E., Liu, W., & Kumaran, D.

Neuron, 112(8), 1201–1217

PDF DOI Cite πŸ”– 89 citations
2023
Conference

Sleep-dependent memory consolidation in large language models: A cross-disciplinary framework

Shaw, E., MartΓ­nez, A., & McClelland, J.L.

NeurIPS 2023, Spotlight Paper

PDF Poster Cite πŸ”– 203 citations
2023
Journal

Longitudinal fMRI tracking of memory circuit reorganization in early Alzheimer's disease

Shaw, E., Torres-Prioris, M.J., Bhatt, P., & Stark, C.

JAMA Neurology, 80(11), 1148–1160

PDF DOI Cite πŸ”– 317 citations
2022
Book Chapter

Complementary memory systems and the origins of intelligence

Shaw, E.

The Oxford Handbook of Human Memory, Vol. II, pp. 342–378

Teaching

Courses Offered

9.01 Graduate

Neuroscience and Behavior

Foundations of systems and cognitive neuroscience. Cellular mechanisms, sensory systems, motor control, and the neural basis of cognition.

πŸ—“ Fall Semester πŸ‘₯ 24 students ⭐ 4.9 / 5.0
9.641J Graduate

Introduction to Neural Networks

Biologically-plausible neural network models; Hopfield networks, Boltzmann machines, and modern deep architectures viewed through a neuroscience lens.

πŸ—“ Spring Semester πŸ‘₯ 36 students ⭐ 4.8 / 5.0
9.110 Undergrad

Memory, Learning & Brain

An undergraduate survey of the cognitive and neural science of memory, from molecular mechanisms to brain-wide systems to clinical implications.

πŸ—“ Spring Semester πŸ‘₯ 120 students ⭐ 4.7 / 5.0
9.912 PhD Seminar

Computational Models of Cognition

Advanced seminar examining Bayesian models, reinforcement learning, and neural network approaches to perception, memory, and decision-making.

πŸ—“ Fall Semester πŸ‘₯ 12 students ⭐ 5.0 / 5.0
Recognition

Honors & Awards

2024

Fellow, National Academy of Sciences

Elected in recognition of distinguished and continuing achievements in original research.

2023

NIH Director's Pioneer Award

$3.5M five-year grant supporting exceptionally creative high-risk/high-reward research.

2022

Cognitive Neuroscience Society Young Investigator Award

Awarded to an early-career researcher who has made significant contributions to cognitive neuroscience.

2021

MIT MacVicar Faculty Fellow

MIT's highest undergraduate teaching award, recognizing outstanding contributions to education.

2019

Named to Nature's 10 β€” Ten People Who Shaped Science

Featured for work linking sleep architecture to memory reactivation mechanisms.

2017

Sloan Research Fellowship

Awarded to outstanding early-career scholars in the sciences, mathematics, and economics.

Get in Touch

Contact Dr. Shaw

Interested in collaboration, speaking engagements, or graduate admission inquiries? Reach out using the form or through the details below.

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Office

Building 46, Room 4082
77 Massachusetts Ave, Cambridge, MA 02139

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Email

eshaw@mit.edu

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Phone

+1 (617) 253-0000

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Office Hours

Tuesdays 2–4pm, Thursdays 10am–12pm

βœ… Message sent! Dr. Shaw typically responds within 3–5 business days.